Patient-Centered Network of Learning Health Systems (LHSNet)

Details and Information

Visit the LHSNet Website

Organization: Mayo Clinic

Principal Investigator: Veronique Roger, MD

Co-Principal Investigator(s): Sundeep Khosla, MD and Nilay Shah, PhD

Program Director: Alex Alexander MPA, MBA

About LHSNet

LHSNet is developing the research infrastructure to transform health care. LHSNet includes nine leading academic medical centers, healthcare systems, public health departments and private health plans across nine states, bringing together a diverse population of over 10 million individual lives.

Our clinical data research network (CDRN)—the Patient-Centered Network of Learning Health Systems (LHSNet)—is designed to support research to improve health care in ways meaningful to patients, their families, and providers. Our network brings together diverse institutions as partners. Approximately 10 million people are served by these partners, including patients in underserved and rural areas. Our goals are to build the infrastructure to (1) facilitate patient-centered outcomes research; (2) support large pragmatic clinical trials, and observational and interventional comparative effectiveness research studies embedded within the healthcare systems; and (3) enable the dissemination, implementation, and evaluation of clinical and community efforts to improve population health.

Key Strengths and Impact Indicators

  • 10 million patients
  • 10 states geographic coverage
  • Goal of three million linked lives in three years
  • Active patient engagement
  • Established collaborative relationships
  • Ethnic and socioeconomic diversity
  • LHS focused on “learn, study, translate, disseminate”
  • Established clinical trial and informatics experience
  • Community partnerships and public health engagement

Initial Network Use-Case

  • High Prevalence Cohort Clinical Condition: Heart failure
  • Rare Disorder Clinical Condition: Osteogenesis Imperfecta
  • Populations Covered by Initial Focus: Children 0-12, children 13-18, children 18-21, adults >65, disabled persons, racial or ethnic minorities, rural, urban, veterans, women, LGBT, socioeconomic/underserved, individuals with multiple conditions, individuals with rare diseases, individuals whose genetic make-up affects medical outcomes, patients with low health literacy/numeracy
Last updated on August 30, 2016